Abstract: The emergence of gene editing to make precise and targeted changes to the genetic code of plants and animals has attracted immense attention for its ability to create new varieties with specific traits more efficiently and accurately than traditional breeding methods. After a brief review of the amazing effects of genome-edited breeding in crops and livestock, this review has focused mainly on studies of the application of gene editing in farmed fish. It has been found that the global advantage of trait improvement in farmed fish in China has been achieved. In the present review, more attention has been paid to the biosafety assessment and management, including food safety and ecological safety, caused by gene edited farmed fish. At last, based on the progress of various techniques of “controllable sterility”, its significant roles on ecological risk prevention, intellectual property protection and marketing promotion of gene edited farmed fish have been introduced and prospected.